by Andy W » 07 Feb 2011, 17:15
Yes, overnight ferry from the Italian Adriatic coast (Ancona, Bari or Brindisi) to Patras, drive from Patras to Piraeus, then overnight ferry from Piraeus to either Symi direct (or direct-ish given how many other places it stops at) or to Rhodes and then on the Proteus or one of the Dodekanisos boats to Symi if travelling on one of the 6 days there isn't a service from Piraeus to Symi.
ANEK, Minoan Lines or Superfast/Blue Star are the companies to look for for the journey from Italy, ANEK do the Piraeus-Symi ferry, Blue Star or Hellenic Seaways the Piraeus-Rhodes crossing.